Before installing NetPyNE, please ensure you have the following installed:

  1. Python 2 or 3 (2.7, 3.6 and 3.7 are supported). Download from the official Python website. Alternatively, you can download the Anaconda Distribution which also includes several data science and visualization packages. If you are using Windows, it is highly recommended that you download the Anaconda distribution.

  2. The pip tool for installing Python packages. See pip installation here.

  3. The NEURON simulator. See NEURON’s installation instructions. If you would like to run parallelized simulations, please ensure you install NEURON with MPI support (see also Quick start guide). Note: the latest NEURON version can be installed simply via: pip install neuron

N.B. Windows users can make use of Windows Subsystem Linux. Getting started is relatively simple.

N.B. Please make sure that all path definitions are included with the installation

Upgrade to the latest released version of NetPyNE via pip

Use this option if you already have NetPyNE installed and just want to update to the latest version.

Linux or Mac OS (from a terminal): pip install netpyne -U

Windows (from a terminal): python -m pip install -U netpyne

Install the development version of NetPyNE via GitHub and pip

The NetPyNE package source files, as well as example models, are available via GitHub at: The following instructions will install the version in the GitHub “development” branch – it will include some of the latest enhancements and bug fixes, but could also include temporary bugs:

  1. git clone

  2. cd netpyne

  3. git checkout development

  4. pip install -e .

pip will add a symlink in the default Python packages directory to the cloned NetPyNE directory (so you don’t need to modify PYTHONPATH). If new changes are available just need to git pull from the cloned NetPyNE directory.

This version can also be used by developers interested in extending the package.

Use a browser-based online version of NetPyNE GUI (beta version)

The NetPyNE GUI is available online at: There is a maximum number of simultaneous users for this online version, so if you can’t log in, please try again later.

Note: the GUI also includes an interactive Python Jupyter Notebook (click “Python” icon at bottom-left) that you can use to directly run NetPyNE code/models (i.e. without using the actual graphical interface).

Installation Troubleshooting

If you have any issues during the installation please post a message with the details to the NetPyNE forum or the NetPyNE GitHub issues .