Multiple schizophrenia-associated genetic variants of a model of primary auditory cortex, and their impact on gamma rhythms. The model includes a detailed reconstructed morphology, models of the dynamics of eleven different ionic channels and a description of the intracellular Ca2+ concentration of a high-complexity, biophysically detailed model of thick-tufted layer 5 pyramidal cell. Due to the computational complexity of the original model, consisting of 196 compartments, a reduced morphology model was used, where passive parameters, ion channel conductances and parameters describing Ca2+ dynamics were properly fitted. The inhibitory cells in the network were based on a model of fast-spiking PV+ basket cells. These two single cell models were combined into a microcircuit network model consisting of 256 excitatory and 64 inhibitory neurons. Cells were connected via AMPA and NMDA receptor-mediated synaptic currents in the case of excitatory connections and GABAA receptor-mediated synaptic currents for inhibitory connections. Additionally, model cells received two types of input, Poissonian noise to all cells representing background activity in the cortex and rhythmic input representing the sensory input during auditory entrainment. A smaller percentage of inhibitory interneurons (35%) received no sensory input drive.
